• Data about the ability of non conventional

  2020-08-08

  

  Data about the ability of non-conventional ligands to operate class-A GPCRs have been accumulating. Specifically, increasing evidence indicates that oxysterols, oxidized derivatives of cholesterol, are involved in many activities that are not strictly associated with cholesterol metabolism and may a

• br Acknowledgments The authors acknowledge funding from

  2020-08-08

  

  Acknowledgments The authors acknowledge funding from the National Key Research and Development Program of China (2016YFA0502900) and the National Science Foundation of China (31570188). Compartment Size Regulation Regulation of compartment size is one of the most fundamental issues in biology

• Here we discuss implications of

  2020-08-07

  

  Here, we discuss implications of several major families of RING-type E3 ubiquitin ligases (MDM, Cullin, GRAIL, TRAF, TRIM) as targets in inflammation and immunity, and provide insights into potential small molecule interventions to mediate the cellular responses (summarized in Table 1). We briefly c

• Induction of DNA double stranded

  2020-08-07

  

  Induction of DNA double stranded breaks (DSBs) by radiation is considered an effective approach for the treatment of cancer (Jeggo and Lobrich, 2007, McKinnon and Caldecott, 2007). Both radiation and a wide range of anticancer agents act by the induction of DSB in cancer cells, thereby causing cell

• Taken together this study gives

  2020-08-07

  

  Taken together, this study gives first insights into the complex effect of DNMT inhibition on pattern separation. Acute administration of RG108 enhanced pattern separation performance measured with the OPS task and increased Bdnf1 expression. However, this effect was only acute, and was not present

• As a measure of target inhibition in

  2020-08-07

  

  As a measure of target inhibition in vivo, a triglyceride tolerance test in mice was carried out with . Since DGAT-1 is highly expressed in the small intestine and catalyzes the rate determining step in triglyceride synthesis, co-dosing of an inhibitor with an oral Ac-IETD-pNA of lipid provides a r

• Dopaminergic signaling involves a delicate balance between D

  2020-08-06

  

  Dopaminergic signaling involves a delicate balance between DA release and re-uptake by the pre-synaptic nerve terminal. Normally, neuronal activation promotes vesicular release of DA into the synapse. DAT removes DA from the synapse and VMAT-2 transports cytoplasmic DA into vesicles for storage, and

• br Experimental Procedures br Author Contributions

  2020-08-06

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported in part by the Novel Bioengineering and Technological Approaches to Solve Two Major Health Problems in Taiwan sponsored by the Taiwan Ministry of Science and Technology Academic Excellence Program under gra

• Collagen compaction and alignment are generated by cell medi

  2020-08-06

  

  Collagen compaction and alignment are generated by cell-mediated contractile forces (Stopak and Harris, 1982). The transmission of actomyosin forces to collagen has been mainly attributed to integrins and the activation of the Rho-ROCK pathway (Clark et al., 2007, Kural and Billiar, 2013, Provenzano

• Introduction Quassinoids are natural products formed through

  2020-08-06

  

  Introduction Quassinoids are natural products formed through the oxidative degradation of triterpene derivatives with anti-inflammatory, antimicrobial, antineoplastic, and antiplasmodial effects (Chakraborty and Pal, 2013; Houël et al., 2013). They are characteristic ingredients of the family Simar

• ZM 306416 We have previously shown that vigilin overexpressi

  2020-08-06

  

  We have previously shown that vigilin overexpression can inhibit breast cancer cell invasiveness and motility in vitro [9]. Here, we show that deletion of the 69 nt vigilin binding element obviates effect of ZM 306416 with excess CSF-1R mRNA 3′UTR on enhancement of in vitro parameters of breast can

• Although differences in several nociceptive

  2020-08-06

  

  Although, differences in several nociceptive tests have previously been described across strains (Mogil et al., 1999), it is the first time that pain sensitivity in response to chemical and thermal stimuli has been evaluated in B6,129CRHtklee mice. Our results showed no differences in pain sensitivi

• br Experimental br Acknowledgments The authors are grateful

  2020-08-06

  

  Experimental Acknowledgments The authors are grateful to Dr. Amany Ameen Sleem, Professor of Pharmacology, Pharmacology Department, National Research Center, Dokki, Giza, Egypt for carrying out the in vivo anti-inflammatory assay and gastric ulcerogenic activity. The authors thank Dr. Esam Ras

• VMD v Humphrey et al was used to

  2020-08-05

  

  VMD v1.9.2 (Humphrey et al., 1996) was used to analyze the MD trajectories, salt bridge interactions and secondary structure information from each frame. Once the model was optimized, the topological diagram and area and volume of protein cavities were analyzed using PDBsum (Laskowski, 2009) and CA

• br Results and discussion br Experimental

  2020-08-05

  

  Results and discussion Experimental procedures Introduction Prolyl 4-hydroxylase (P4H) is a key enzyme of the collagen biosynthesis catalyzing the hydroxylation of proline residues in -Xaa-Pro-Gly-sequences typical of proteins with collagen domains (for review, see Kivirikko et al., 1989, K

16435 records 828/1096 page Previous Next First page 上5页 826827828829830 下5页 Last page