• In a recent series of studies from our

  2024-12-21

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat OG-L002 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contra

• Recently biosensors based on enzyme mimicking

  2024-12-21

  

  Recently, biosensors based on enzyme-mimicking organic-inorganic hybrid nanomaterials such as protein or DNA-Cu nanoflowers (Batule et al., 2015, Park et al., 2017), Fe-aminoclay (Lee et al., 2013), and MOFs (Ai et al., 2013, Dong et al., 2015, Feng et al., 2012, Liu et al., 2013, Qin et al., 2013,

• br Dihydrotestosterone in adult fish and frogs br New

  2024-12-21

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• ASK belongs to the family of

  2024-12-20

  

  ASK1 belongs to the family of MAPKKK. ASK1-mediated apoptosis is involved in the pathogenesis of several diseases such as I/R injury, infectious diseases and neurodegenerative disorders [33], [34], [35]. ASK1 can be activated through different mechanisms. One mechanism is that oxidative stress direc

• Estrogen exerts its genomic action via

  2024-12-20

  

  Estrogen exerts its genomic action via T7 Tag Peptide nuclear receptor: ERα and ERβ. The distribution of ERα and/or ERβ positive neurons in CNS of different species has been mapped extensively by various methods [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], although there are some dif

• Two major categories of arginase inhibitors

  2024-12-20

  

  Two major categories of arginase inhibitors have been distinguished (Fig. 3): the first category comprises synthetic arginase inhibitors, which have been developed from the substrate l-arginine [35]; and the second category includes inhibitors derived from natural products [36]. The category of synt

• br Introduction Endothelial progenitor cells EPCs present a

  2024-12-20

  

  Introduction Endothelial progenitor cells (EPCs) present a class of blood cells with an ability to form new blood vessels relying on pre-existing vessels, which contribute to postnatal angiogenesis [1], [2]. A wide range of studies have demonstrated that EPCs play a critical role in angiogenesis

• br Introduction The term antioxidant derives from

  2024-12-20

  

  Introduction The term antioxidant derives from the prevention of the oxygen consumption. In the late of 19th centuries, antioxidants were generally used in industrial processes such as against to metal corrosion, vulcanization of rubber. Later on, the use of antioxidants to prevent the rancidity

• DiscoveryProbe immunology research In human epidermoid carci

  2024-12-20

  

  In human epidermoid carcinoma A431 cells, 12-lipoxygenase was significantly increased in glutathione-depleted cells. The relative abundance of phospholipid hydroperoxide versus glutathione peroxidase seems to play an important role in controlling the lipoxygenase reaction [57]. It has been proposed

• Targeted disruption of the Akt gene in mice induces

  2024-12-20

  

  Targeted disruption of the Akt1 gene in mice induces a growth retardation phenotype [4,19]. Akt2 KO mice reveal mild growth retardation and insulin resistance [4,20,21]. Akt1/2 double KO (DKO) mice display severe growth deficiency and die shortly after birth. These mice exhibit impaired bone and ski

• br Discussion Here we show opposing effects of iontophoretic

  2024-12-20

  

  Discussion Here, we show opposing effects of iontophoretically administered phenylephrine,aselective α1-AR agonist, on firing of putatively DAergic and non-DAergic neurons recorded in vivo in the VTA of urethane anaesthetized rats. Phenylephrine application caused a relatively weak decrease in fi

• Moreover an increase of extracellular calcium stimulates

  2024-12-20

  

  Moreover, an increase of extracellular calcium stimulates BMP-2 expression of pulp AZD1390 synthesis via L-type calcium channel and ERK signaling, which can be attenuated by PD98059 and nifedipine . Dental pulp cells expressed little calcium-sensing receptors . immunohistochemistry staining also s

• br Difference between ACh and ER tests There are few

  2024-12-19

  

  Difference between ACh and ER tests There are few reports concerning the provoked spasm between ER and ACh in the same patients [51], [52], [53]. Different mediators may have the potential of different coronary responses. In our experience, spasm provoked by intracoronary injection of ER is focal

• br Role of LPA in

  2024-12-19

  

  Role of LPA in tumor angiogenesis and skeletal metastasis The angiogenesis switch is essential for tumor expansion and escape of tumor Deacetylase Inhibitor Cocktail from the primary site and forming distant metastases. Evidence for the role of LPA2 and LPA3 in the mobility of endothelial cells a

• br Acknowledgement This work was funded

  2024-12-19

  

  Acknowledgement This work was funded by NIH/NINDS grant number NS080967 to C. Waites. Introduction Macro-autophagy also called autophagy is a conserved pathway for the lysosomal degradation and recycling of intracellular materials. It is instrumental for the homeostasis of cells and tissues a

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